Elsa Yan

Professor of Chemistry
Member of Yale faculty since 2007

E-mail: elsa.yan@yale.edu
Web site: http://ursula.chem.yale.edu/~yanlab/Index.html

Research We are interested in understanding biological phenomena related to biomembranes at the molecular level.  We focus on protein folding at membrane surfaces and signal transduction across biomembranes through G protein-coupled receptors (GPCRs). Using techniques in molecular biology and chemical biology, we express and purify recombinant soluble and membrane proteins. We then apply second-order laser spectroscopy and biophysical methods to obtain thermodynamic and kinetic information to investigate structure and functions of the proteins.

Education
B.S. Chinese University of Hong Kong, Hong Kong, 1995
Ph.D. Columbia University, 2000
Postdoctoral Fellow, University of California, Berkeley, 2000-2004
Visiting Fellow, HHMI, Rockefeller University, New York, 2000-2004
Research Assistant Professor, Rockefeller University, New York, 2004-2007

Honors
Sir Edward Youde Memorial Scholarship, Hong Kong, 1994
First Class Honors for B.Sci., Chinese University of Hong Kong, Hong Kong, 1995
Distinction for Ph.D., Columbia University, New York, 2000
Pegram Award for graduate research, Columbia University, New York, 2000
Petroleum Research Fund Award, American Chemical Society, 2009-2011
Starter Grant Award, Spectroscopy Society of Pittsburgh, 2009-2010
NSF CAREER Award, National Science Foundation, 2010-2015
Tour speaker, Society of Applied Spectroscopy, 2011
The Greer Memorial Prize for Achievement in Research in Nature Sciences, Yale University, 2011
Early Excellent in Physical Organic Chemistry, Journal of Physical Organic Chemistry, 2012
Elected Vice Chair, Gordon Research Conference: Vibrational Spectroscopy, 2014
Elected Chair, Gordon Research Conference: Vibrational Spectroscopy, 2016

Recent Publications

M.Y. Liu, J. Liu, D. Mehrotra, Y. Liu, Y. Guo, P.A. Baldera-Aguayo, V.L. Mooney, A.M. Nour, E.C.Y. Yan. Thermal Stability of Rhodopsin and Progression of Retinitis Pigmentosa: A Comparison of S186W and D190N Rhodopsin Mutants J. Biol. Chem. 2013, in press.

Z. Wang, L. Fu, E.C.Y. Yan, C-H Stretch for Probing Self-Assembly of LK7β into Chiral Macromolecular Structures at the Air-Water Interface by Chiral Sum Frequency Generation Spectroscopy. Langmuir 2013, 29, 4077.

L. Fu, D.Q. Xiao, Z. Wang, V.S. Batista, E.C.Y. Yan. Chiral Sum Frequency Generation for Probing the Hydrogen/Deuterium Exchange in Antiparallel b-Sheet Peptides at Interfaces. J. Am. Chem. Soc. 2013, 135, 3592.

N. Mitra, Y. Liu, J. Liu, E. Serebryany, V. Mooney, B.T. DeVree, R. Sunahara, E.C.Y. Yan. Calcium Dependent Ligand Binding and G-protein Signaling of Family B GPCR Parathyroid Hormone 1 Receptor Purified in Nanodiscs. ACS Chem. Biol. 2013, 8, 617.

D. Xiao, L. Fu, J. Liu, V.S. Batista, & E.C.Y Yan. Amphiphilic Adsorption of Human Islet Amyloid Polypeptide Aggregates to Lipid/Aqueous Interfaces. J. Mol. Biol. 2012, 421, 537.

V.L. Mooney, I. Szundi, J.W. Lewis, E.C.Y Yan, & D.S. Kliger. Schiff Base Protonation Changes in Siberian Hamster Ultraviolet Cone Pigment Photointermediates. Biochemistry 2012, 51, 2603.

J. Liu, M. Liu, L. Fu, & E.C.Y Yan. Chemical Kinetic Analysis of Thermal Decay of Rhodopsin Reveals Unusual Energetics of Thermal Isomerization and Hydrolysis of Schiff Base. J. Biol. Chem. 2011, 286, 38408.

J. Liu, M. Liu, V. Mooney, A. Bhagat, J. Nguyen, & E.C.Y Yan. Thermal Properties of Rhodopsin: Insight into Molecular Mechanism of Dim-Light Vision. J. Biol. Chem. 2011, 286, 27622.

L. Fu, J. Liu, E.C.Y. Yan. Chiral Sum Frequency Generation Spectroscopy for Characterizing Protein Secondary Structures at Interfaces. J. Am. Chem. Soc. 2011, 133, 8094.

L. Fu, G. Ma, E.C.Y. Yan. In Situ Misfolding of Human Islet Amyloid Polypeptide at Interfaces Probed by Sum Frequency Generation. J. Am. Chem. Soc. 2010, 132, 5405.

Elsa Yan

Research Interests