H.H. Wasserman

Eugene Higgins Professor Emeritus
Member of Yale faculty since 1948

E-mail: harry.wasserman@yale.edu

Research My research interests have involved the chemistry of reactive intermediates with the goal of developing new reactions applicable to the field of organic synthesis. Many of these methods have been applied in the synthesis of bioactive products such as marine metabolites, protease inhibitors and immunosuppressants. Among reagents studied have been singlet oxygen and vicinal tricarbonyls used as polyelectrophiles.

Education
B.S. Massachusetts Institute of Technology, 1941
Ph.D. Harvard University, 1949

Honors
Member, American Academy of Arts and Sciences
Member, National Academy of Sciences
Member of the Board of Directors, The Camille and Henry Dreyfus Foundation
Guggenheim Fellow, 1959
Chemical Manufacturers Association Catalyst Award, 1985
ACS Aldrich Award in Synthetic Organic Chemistry, 1987
Cope Scholar Award, 1990
Merit Award, N.I.H., 1994

Recent Publications
H. H. Wasserman, Y. O. Long, R. Zhang, & J. Parr, Formation of Heterocyclic Derivatives of α-Amino Acids Using Vicinal Tricarbonyl Methodology. Heterocycles 2002, 58, 393.

H. H. Wasserman, Y.O. Long, & J. Parr, α,β-Diketo Nitriles as Dielectrophiles. Formation of Heterocyclic Derivatives of Amino Acids, Tetrahedron Letters 2003, 44, 361.

H. H. Wasserman, A.K. Petersen, & M. Xia. Application of Acyl Cyanophosphorane Methodology to the Synthesis of Protease Inhibitors. Poststatin, Eurystatin, Phebestin, Probestin and Bestatin, Tetrahedron 2003, 59, 6771.

H.H. Wasserman & J. Parr. The Chemistry of Vicinal Tricarbonyls and Related Systems. Accounts of Chemical Research 2004, 37, 687-701.

H. H. Wasserman, M. Xia, J. Wang, A. K. Petersen, M. Jorgensen, P. Power, & J. Parr. Singlet oxygen reactions of 3-methoxy-2-pyrrole carboxylic acid tert-butyl esters. A route to 5-substituted pyrrole precursors of prodigiosin and analogs, Tetrehedron 2004, 60, 7419.

H.H. Wasserman

Research Interests