Department of Chemistry
Yale University
225 Prospect Street
PO Box 208107
New Haven CT 06520 8107
203 432 3915

David A. Spiegel

Associate Professor of Chemistry
Member of Yale faculty since 2007

E-mail: david.spiegel@yale.edu
Web site: http://www.spiegelgroup.yale.edu

Research The Spiegel lab develops novel chemical methods to enable the synthesis of a variety of complex molecular targets, including natural products. These synthetic materials will be used to study the molecular mechanisms that underlie human disease processes (e.g., cancer, Alzheimer’s disease, and diabetes) as well as to develop novel therapeutic approaches to these conditions. Overall, students in the Spiegel lab receive in-depth training in organic synthesis as well as to techniques in molecular and cellular biology.

Education
NIH Postdoctoral Fellow, Harvard University (Stuart L. Schreiber), 2005-2007
M.D. Yale University, 2004
Ph.D. Yale University (John L. Wood), 2004
A.B. Harvard University, 1995

Honors
Bill and Melinda Gates Foundation Grand Challenges Explorations Award, 2009-present
Ellison Medical Foundation New Scholar Award, 2008-present
NIH Director's New Innovator Award, 2007-present
Dreyfus New Faculty Award 2007-present
NIH Ruth L. Kirchstein National Research Service Award Fellowship, 2005-07
NIH Cancer Education Program Fellowship, 2001-02
Rotary Foundation Walter D. Head Memorial Fellowship for Study Abroad, 1995-96
Barry M. Goldwater Fellowship for Excellence in Science, 1994-95
Rockefeller University Summer Undergraduate Research Fellowship, 1994
John Harvard Fellowship (awarded by semester), 1992-95

Recent Publications

J.W. Nelson, A.G. Chamessian, P.J. McEnaney, B.I. Kazmierczak, & D.A. Spiegel. A Biosynthetic Strategy for Re-engineering the S. aureus Cell Wall with Non-Native Small Molecules. ACS Chemical Biology. 2010, 1147-1155.

D.A. Spiegel. Synthetic Immunology to Engineer Human Immunity. Nat. Chem. Biol. 2010, 6, 871-872.

A.X. Zhang, R.P. Murelli, C. Barinka, J. Michel, A. Cocleaza, W.L. Jorgensen, J. Lubkowski, D.A. Spiegel. A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules. J. Am. Chem. Soc. 2010, 132, 12711-12716.

R.M. Murelli, A.X. Zhang, J. Michel, W.L. Jorgensen, & D.A. Spiegel. Chemical control over immune recognition: A class of antibody-recruiting small molecules that target prostate cancer. J. Am. Chem. Soc., 2009, 131, 17090-17092.  This work was featured as a news story in ACS Chemical Biology, 2009, 4, 975, and was highlighted online by Faculty of 1000 Biology, Popular Science, e! Science News, Science Daily, and Genetic Engineering & Biotechnology News.

C.G. Parker, R.A. Domaoal, K.S. Anderson, & D.A. Spiegel.  An antibody-recruiting small molecule that targets HIV gp120. J. Am. Chem. Soc., 2009, 131, 16392-16394. This work was featured as a news story in ACS Chemical Biology, 2009, 4, 975, and was highlighted online by Popular Science, e! Science News, Science Daily, R&D Magazine, Genetic Engineering & Biotechnology News, and ACS Noteworthy Chemistry.

E. Stern, S.M. Jay, S.L. Demento, R.P. Murelli, M.A. Reed, T. Malinski, D.A. Spiegel, D.J. Mooney, & T.M. Fahmy.  Spatiotemporal control over molecular delivery and cellular encapsulation from electropolymerized micro- and nanopatterned surfaces.  Adv. Funct. Mater., 2009, 19, 2888-2895.

M.R. Medeiros, L.N. Schacherer, D.A. Spiegel, & J.L. Wood, J. L. Expanding the scope of trialkylborane/water-mediated radical reactions. Org. Lett.
2007, 9, 4427-4429.

D.A. Spiegel, F.C. Schroeder, J.R. Duvall, & S.L. Schreiber. An oligomer-based approach to skeletal diversity in small molecule synthesis. J. Am. Chem. Soc. 2006, 128, 14766. This work was featured as a Science and Technology Concentrate in C&E News, 2006, 84, 35.

D. A. Spiegel, K. B. Wiberg, L. N. Schacherer, M. R. Medeiros, & J. L. Wood. Deoxygenation of alcohols employing water as the hydrogen atom source. J. Am. Chem. Soc., 2005, 127, 12513-12515. This work was featured as a news story in C&E News 2005, 83, 9.