David A. Spiegel

Professor of Chemistry
Member of Yale faculty since 2007

E-mail: david.spiegel@yale.edu
Web site: http://www.spiegelgroup.yale.edu

Research The Spiegel lab develops novel chemical methods to enable the synthesis of a variety of complex molecular targets, including natural products. These synthetic materials will be used to study the molecular mechanisms that underlie human disease processes (e.g., cancer, Alzheimer’s disease, and diabetes) as well as to develop novel therapeutic approaches to these conditions. Overall, students in the Spiegel lab receive in-depth training in organic synthesis as well as to techniques in molecular and cellular biology.

Education
NIH Postdoctoral Fellow, Harvard University (Stuart L. Schreiber), 2005-2007
M.D. Yale University, 2004
Ph.D. Yale University (John L. Wood), 2004

A.B. Harvard University, 1995

Honors
American Chemical Society Committee on Science Young Investigator Awardee, 2013
Department of Defense CDMRP Breast Cancer Era of Hope Scholar Award, 2013
ACS Medicinal Chemistry Young Investigator Award Symposium Speaker, 2012
Bristol-Myers Squibb Innovation Award, 2012
Novartis Early Career Award in Organic Chemistry (one of two recipients worldwide), 2011
Kavli Institute Frontiers of Science Fellowship, 2011
Alfred P. Sloan Foundation Fellowship, 2011
Nature Chemical Biology Grand Challenges Essay Contest, 2010
Bill and Melinda Gates Foundation Grand Challenges Explorations Award, 2009-present
Ellison Medical Foundation New Scholar Award, 2008-present
NIH Director's New Innovator Award, 2007-present
Dreyfus New Faculty Award 2007-present
NIH Ruth L. Kirchstein National Research Service Award Fellowship, 2005-07
NIH Cancer Education Program Fellowship, 2001-02
Rotary Foundation Walter D. Head Memorial Fellowship for Study Abroad, 1995-96
Barry M. Goldwater Fellowship for Excellence in Science, 1994-95
Rockefeller University Summer Undergraduate Research Fellowship, 1994
John Harvard Fellowship (awarded by semester), 1992-95

Recent Publications

D.A. Spiegel. A Call to ARMs. The Promise of Small Molecule Immunotherapeutics for Treating Human Disease. Expert Rev Clin Pharmacol. 2013, 6, 223–225.

E.F. Douglass, C.J. Miller, G. Sparer, H.N. Shapiro, & D.A. Spiegel. A Comprehensive Mathematical Model for Three Body Binding Equilibria. J. Am. Chem. Soc. 2013, 135, 6092–6099.

P.J. McEnaney, T. Padukkavidana, & D.A. Spiegel. “Synthetic Immunology”. In Biotherapeutics: Recent Developments using Chemical and Molecular Biology, Lyn Jones, Ed. (Royal Society of Chemistry, 2013), in press.

S. Gautam, T. Gniadek, T. Kim, & D.A. Spiegel. Exterior Design: Strategies for Redecorating the Bacterial Surface with Small Molecules. Trends Biotechnol. 2013, 31, 258–267.

T. Kim & D.A. Spiegel. The Unique Reactivity of N-phenacyl-derived Thiazolium Salts Toward a-Dicarbonyl Compounds. Rejuvenation Res. 2013, 16, 43–50.

P.J. McEnaney, C.G. Parker, A.X. Zhang, & D.A. Spiegel. Antibody-Recruiting Molecules: An Emerging Paradigm for Engaging Immune Function in Treating Human Disease. ACS Chem. Biol. 2012, 7, 1139–1151.

T. Wang, K. Kartika, & D.A. Spiegel. Exploring Post-Translational Arginine Modification Using Chemically Synthesized Methylglyoxal Hydroimidazolones (MG-Hs). J. Am. Chem. Soc. 2012, 134, 8959–8967.

C.E. Jakobsche, P.J. McEnaney, A.X. Zhang, & D.A. Spiegel. Reprogramming Urokinase in an Antibody-Recruiting Anticancer Agent. ACS Chem. Biol. 2012, 7, 316–321.

A. Dubrovska, C. Kim, J. Elliot, W. Shen, T-H Kuo, D-I Koo, C. Li, T. Tuntland, J. Chang, T. Groessl, X. Wu, D.A. Spiegel, C.Y. Cho, & P.G. Schultz. A Chemically Induced Vaccine Strategy for Prostate Cancer. ACS Chem. Biol. 2011, 6, 1223–1231.

J.E. Hendrickson, E.A. Hod, C.M. Cadwell, S.C. Eisenbarth, D.A. Spiegel, C.A. Tormey, S.L. Spitalnik, & J.C. Zimring. Rapid Clearance of Transfused Murine RBCs is Associated with Recipient Cytokine Storm and Enhanced Alloimmunogenicity. Transfusion. 2011, 51, 2445–2454.

J.W. Nelson, A.G. Chamessian, P.J. McEnaney, B.I. Kazmierczak, & D.A. Spiegel. A Biosynthetic Strategy for Re-engineering the S. aureus Cell Wall with Non-Native Small Molecules. ACS Chem. Biol. 2010, 1147-1155.

D.A. Spiegel. Synthetic Immunology to Engineer Human Immunity. Nat. Chem. Biol. 2010, 6, 871-872. Chosen as one of eight recipients of the 2010 Grand Challenges in Chemical Biology Competition.

A.X. Zhang, R.P. Murelli, C. Barinka, J. Michel, A. Cocleaza, W.L. Jorgensen, J. Lubkowski, D.A. Spiegel. A remote arene-binding site on prostate specific membrane antigen revealed by antibody-recruiting small molecules. J. Am. Chem. Soc. 2010, 132, 12711-12716.

R.M. Murelli, A.X. Zhang, J. Michel, W.L. Jorgensen, & D.A. Spiegel. Chemical control over immune recognition: A class of antibody-recruiting small molecules that target prostate cancer. J. Am. Chem. Soc., 2009, 131, 17090-17092.  This work was featured as a news story in ACS Chemical Biology, 2009, 4, 975, and was highlighted online by Faculty of 1000 Biology, Popular Science, e! Science News, Science Daily, and Genetic Engineering & Biotechnology News.

C.G. Parker, R.A. Domaoal, K.S. Anderson, & D.A. Spiegel.  An antibody-recruiting small molecule that targets HIV gp120. J. Am. Chem. Soc., 2009, 131, 16392-16394. This work was featured as a news story in ACS Chemical Biology, 2009, 4, 975, and was highlighted online by Popular Science, e! Science News, Science Daily, R&D Magazine, Genetic Engineering & Biotechnology News, and ACS Noteworthy Chemistry.

E. Stern, S.M. Jay, S.L. Demento, R.P. Murelli, M.A. Reed, T. Malinski, D.A. Spiegel, D.J. Mooney, & T.M. Fahmy.  Spatiotemporal control over molecular delivery and cellular encapsulation from electropolymerized micro- and nanopatterned surfaces.  Adv. Funct. Mater., 2009, 19, 2888-2895.

David A. Spiegel

Research Interests