David A. Spiegel

Assistant Professor of Chemistry
Member of Yale faculty since 2007

E-mail: david.spiegel@yale.edu
Web site: http://www.spiegelgroup.yale.edu

Research The Spiegel lab develops novel chemical methods to enable the synthesis of a variety of complex molecular targets, including natural products. These synthetic materials will be used to study the molecular mechanisms that underlie human disease processes (e.g., cancer, Alzheimer’s disease, and diabetes) as well as to develop novel therapeutic approaches to these conditions. Overall, students in the Spiegel lab receive in-depth training in organic synthesis as well as to techniques in molecular and cellular biology.

Education
A.B. Harvard University, 1995
Ph.D. Yale University (John L. Wood), 2004
M.D. Yale University, 2004
NIH Postdoctoral Fellow, Harvard University (Stuart L. Schreiber), 2005-2007

Honors
John Harvard Fellowship (awarded by semester), 1992-95
Rockefeller University Summer Undergraduate Research Fellowship, 1994
Barry M. Goldwater Fellowship for Excellence in Science, 1994-95
Rotary Foundation Walter D. Head Memorial Fellowship for Study Abroad, 1995-96
NIH Cancer Education Program Fellowship, 2001-2002
NIH Ruth L. Kirchstein National Research Service Award Fellowship, 2005-2007
Dreyfus New Faculty Award 2007-present
NIH Director's New Innovator Award, 2007-present
Ellison Medical Foundation New Scholar Award, 2008-present

Recent Publications
D. A. Spiegel, J. T. Njardarson, & J. L. Wood. CP-263,114 Synthetic studies. Construction of an isotwistane ring system via rhodium carbenoid C-H insertion. Tetrahedron 2002, 58, 6545-6554.

D. A. Spiegel, J. T. Njardarson, I. M. McDonald, & J. L. Wood. Innovation and Art in Organic Chemistry: Synthetic Efforts Toward the Phomoidrides. Chem. Rev., 2003, 103, 2691-2727.

D. A. Spiegel, K. B. Wiberg, L. N. Schacherer, M. R. Medeiros, & J. L. Wood. Deoxygenation of Alcohols Employing Water as the Hydrogen Atom Source. J. Am. Chem. Soc., 2005, 127, 12513-12515.

D.A. Spiegel, F.C. Schroeder, J.R. Duvall, & S.L. Schreiber. An Oligomer-based Approach to Skeletal Diversity in Small Molecule Synthesis. J. Am. Chem. Soc. 2006, 128, 14766.

M.R. Medeiros, L.N. Schacherer, D.A. Spiegel, & J.L. Wood, J. L. Expanding the Scope of Trialkylborane/Water-Mediated Radical Reactions. Organic Letters
2007, 9, 4427-4429.

David A. Spiegel

Research Interests