Scott J. Miller

Irénée du Pont Professor and Chair of Chemistry
Member of Yale faculty since 2006

E-mail: scott.miller@yale.edu
Web site: http://www.yale.edu/millerlab

Research Complex molecule synthesis is one of the key disciplines of modern chemical research. The development of new methods for the synthesis and derivatization of such structures is a multi-dimensional activity involving reaction design, development, and application. Research in our group focuses on each of these aspects of chemical synthesis. Utilizing the architecture and design principles presented by biologically relevant structures and processes, we seek to discover new reactions and to apply new principles to the selective synthesis of complex molecules.

As part of this program, we bring to bear the full arsenal of modern synthetic chemistry. Employing rational design, combinatorial screening and a constantly evolving collective intuition, we are working to discover new chemical transformations that enable the rapid synthesis of stereochemically complex structures. In addition, we are investigating the development of new catalysts for the selective functionalization of these molecules.

A particular interest is in the catalytic modification of natural products. These studies are enabling access to an expansive set of biologically inspired natural product analogs. A key component of all of this work is the determination of the fundamental molecular interactions that are responsible for reaction selectivities. As a result, mechanistic analysis is at the heart of many of our studies.

Education
B.S. Harvard University, 1989
Ph.D. Harvard University, 1994
NSF Postdoctoral Fellow, California Institute of Technology, 1994-96

Honors
Research Innovation Award, Research Corporation, 1998
NSF CAREER Award, 1999
Cottrell Scholar Award of Research Corporation, 1999
Eli Lilly Grantee, 1999
Novartis Chemistry Lectureship Award, 1999
DuPont Young Professor Award, 2000
Camille Dreyfus Teacher-Scholar Award, 2000
Glaxo-Wellcome Chemistry Scholar Award, 2000
Alfred P. Sloan Research Fellowship, 2000
Merck Chemistry Council Grants, 2000-2007
Pfizer Award for Creativity in Organic Chemistry, 2003
Arthur C. Cope Scholar Award, American Chemical Society, 2004
Robert Burns Woodward Visiting Scholar, Harvard University, 2005
Boehringer-Ingelheim Cares Foundation Award, 2006
Yoshimasa Hirata Memorial Gold Medal, Nagoya University, 2009
National Institutes of Health MERIT Award, 2011

Representative Publications
C.A. Lewis & S.J. Miller. Site-Selective Derivatization and Remodeling of Erythromycin A Using Peptide-Based Chiral Catalysts. Angew. Chem. Int. Ed. 2006, 45, 5616-5619. See also “Editor’s Choice” Science 2006, 313, 592-593.

C.E. Aroyan & S.J. Miller. Enantioselective Rauhut-Currier Reactions Promoted By Protected Cysteine. J. Am. Chem. Soc. 2007, 129, 256-257.

G. Peris, C.E. Jakobsche, & S.J. Miller. Aspartate-Catalyzed Asymmetric Epoxidation Reactions. J. Am. Chem. Soc. 2007, 129, 8710-8711.

K.W. Fiori, A.L.A. Puchlopek, & S.J. Miller. Enantioselective Sulfonylation Reactions Mediated by a Tetrapeptide Catalyst. Nature Chem. 2009, 1, 630-634.

J. Gustafson, D. Lim, & S.J. Miller. Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Asymmetric Bromination. Science 2010, 328, 1251-1255.

Scott J. Miller

Research Interests