Assistant Professor of Chemistry
Member of Yale faculty since 2010
Research The Baxter lab is interested in the innate immune response of
arthropods, especially the complement-like system in Anopheles gambiae,
host-pathogen interactions, and the development of new chemical entities
for the control of vector-borne disease. Our primary research tools are
biophysical methods, including macromolecular crystallography and
small-angle x-ray scattering, biochemistry and chemical biology. Our
approach is multi-disciplinary and interfaces with both cross-campus and
international collaborators studying vector biology and infectious disease.
B.Sc. (Hons.) Australian National University, 1998
Ph.D. University of Chicago, 2004
Boomerang Award, Australian National University, 2009
NIAID Research Scholar (K22) Award, 2010
R.H.G. Baxter, C.-I Chang, Y. Chelliah, S. Blandin, E.A. Levashina, & J. Deisenhofer. Structural basis for conserved complement factor-like function in the antimalarial protein TEP1. Proc. Nat. Acad. Sci. USA 2007, 104, 11615-20.
M. Fraiture, R.H.G. Baxter, S. Steinert, Y. Chelliah, C. Frolet, W. Quispe-Tintaya, J.A. Hoffmann, S.A. Blandin, & E.A. Levashina. Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium. Cell Host Microbe 2009, 5, 273-84.
R.H.G. Baxter, S. Steinert, Y. Chelliah, G. Volohonsky, E.A. Levashina, & J. Deisenhofer. A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae. Proc. Nat. Acad. Sci. USA 2010, in press.