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Sidney Altman

Sterling Professor of Molecular Cellular and Developmental Biology, Professor of Chemistry, Biophysical Chemistry & Organic Chemistry
E-mail: sidney.altman@yale.edu
Web site: http://www.biology.yale.edu/facultystaff/altman.html

Biographical Sketch

B.S. Massachusetts Institute of Technology, 1960
Ph.D. University of Colorado, 1967
Postdoctoral Fellow, Harvard University, 1967-69
Visiting Research Fellow, MRC Laboratory, Cambridge, England, 1969-71
Joined Yale faculty 1971.
Nobel Prize in Chemistry, 1989
American Academy of Arts and Sciences National Academy of Sciences, 1990
Honorary Degrees: Université de Montréal 1990, York University (Toronto) 1990, Connecticut College 1990, McGill University 1991, University of Colorado 1991, University of British Columbia 1991, Dartmouth College 1996.

Research Description

Our lab is concerned with the function and structure of ribonuclease P in both bacteria and human cells. We investigate the properties of these enzymes and what they are doing in vivo. We are also exploring the use of RNase P and so-called external guide sequences to activate various genes in bacteria and mammalian cells.

Selected References

• Pomeranz Krummel, D.A. and Altman, S. Verification of phylogenetic predictions in vivo and the importance of the tetraloop motif in a catalytic RNA. 1999. Proc. Nat. Acad. Sci. USA., 96:11200-11205.
• Li, Yong and Altman, S. A subunit of human nuclear RNase P has ATPase activity. 2001. Proc. Nat. Acad. Sci. USA, 98:441-444.
• Gopalan, V., Vioque, A. and Altman, S. Varieties of RNase P: A nomenclature problem? 2000. RNA, 6:1689-1694.
• Jiang, T. and Altman, S. Protein-protein interactions with subunits of human nuclear RNase P. 2001. Proc. Nat. Acad. Sci. USA, 98:920-925.
• Paul, R., Lazarev, D. and Altman, S. Characterization of RNase P from Thermotoga maritima. 200l. Nucl. Acids Res. 29(4):880-885.

Last modified: July 10, 2005 (kp)